M Flint Beal Selected Research

Mitochondrial DNA (mtDNA)

10/2016	Mitochondrial dysfunction in Parkinson's disease.
7/2013	Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases.
6/2012	Somatic mitochondrial DNA mutations in early Parkinson and incidental Lewy body disease.
12/2009	Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease.
12/2008	Mitochondrial approaches for neuroprotection.
2/2007	Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders.
1/2007	Mitochondria and neurodegeneration.
10/2006	Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.
4/2006	Does the mitochondrial genome play a role in the etiology of Alzheimer's disease?
7/2004	Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication.

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M Flint Beal Research Topics

Disease

60	Parkinson Disease (Parkinson's Disease) 12/2020 - 04/2002
46	Huntington Disease (Huntington's Disease) 10/2019 - 01/2002
42	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2020 - 01/2002
35	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2016 - 04/2002
32	Mitochondrial Diseases (Mitochondrial Disease) 12/2020 - 02/2002
31	Alzheimer Disease (Alzheimer's Disease) 10/2022 - 01/2002
12	Inflammation (Inflammations) 01/2018 - 06/2003
9	Disease Progression 05/2014 - 11/2005
8	Atrophy 03/2014 - 03/2002
8	Weight Loss (Weight Reduction) 11/2009 - 03/2002
6	Gliosis 08/2007 - 02/2005
5	Stroke (Strokes) 05/2014 - 06/2004
5	Hypoxia (Hypoxemia) 04/2011 - 07/2002
4	Cognitive Dysfunction 05/2022 - 02/2008
4	Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked) 01/2022 - 08/2013
4	Parkinsonian Disorders (Parkinsonism) 05/2014 - 01/2004
4	Dementia (Dementias) 01/2012 - 09/2002
3	Multiple Sclerosis 01/2018 - 07/2008
3	Tauopathies 01/2018 - 12/2012
3	Memory Disorders (Memory Loss) 04/2014 - 08/2009
3	Brain Ischemia (Cerebral Ischemia) 01/2005 - 06/2003
3	Ischemia 06/2004 - 07/2002
2	Thiamine Deficiency 01/2018 - 10/2009
2	Neuroinflammatory Diseases 01/2016 - 07/2011
2	Infections 10/2013 - 01/2010
2	Nervous System Diseases (Neurological Disorders) 08/2012 - 10/2009
2	Frontotemporal Dementia (Semantic Dementia) 12/2010 - 02/2008
2	Hypersensitivity (Allergy) 12/2009 - 09/2005
2	Amyloid Plaque 10/2009 - 02/2009
2	Friedreich Ataxia (Friedreich's Ataxia) 01/2009 - 01/2003

Drug/Important Bio-Agent (IBA)

22	Proteins (Proteins, Gene)FDA Link 10/2022 - 05/2002
20	Neuroprotective AgentsIBA 10/2019 - 01/2003
19	AntioxidantsIBA 07/2014 - 03/2002
16	coenzyme Q10 (CoQ10)IBA 05/2014 - 03/2002
14	Mitochondrial DNA (mtDNA)IBA 10/2016 - 01/2002
14	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2016 - 01/2003
12	CreatineIBA 05/2011 - 05/2002
9	Amyloid beta-PeptidesIBA 05/2022 - 11/2002
9	EnzymesIBA 01/2018 - 02/2002
8	Glucose (Dextrose)FDA LinkGeneric 10/2022 - 12/2002
8	Superoxide Dismutase-1IBA 08/2007 - 08/2002
7	Matrix Metalloproteinases (MMPs)IBA 02/2008 - 06/2003
6	Amyloid (Amyloid Fibrils)IBA 05/2022 - 01/2007
6	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2016 - 07/2008
6	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2012 - 09/2005
6	Phosphotransferases (Kinase)IBA 04/2011 - 11/2005
5	Ketoglutarate Dehydrogenase Complex (Oxoglutarate Dehydrogenase)IBA 01/2018 - 03/2004
5	3-nitropropionic acidIBA 04/2011 - 07/2002
5	Dopamine (Intropin)FDA LinkGeneric 04/2011 - 01/2003
5	Therapeutic UsesIBA 03/2008 - 03/2002
5	Free RadicalsIBA 01/2007 - 05/2002
4	Pharmaceutical PreparationsIBA 01/2020 - 07/2004
4	DNA (Deoxyribonucleic Acid)IBA 10/2016 - 04/2005
4	Messenger RNA (mRNA)IBA 04/2014 - 07/2004
4	TriterpenesIBA 01/2013 - 12/2008
4	Biomarkers (Surrogate Marker)IBA 05/2012 - 02/2007
4	Leucine (L-Leucine)FDA Link 04/2011 - 11/2005
4	PPAR gammaIBA 09/2010 - 12/2008
4	Histone Deacetylase InhibitorsIBA 01/2008 - 01/2005
4	Matrix Metalloproteinase 9 (Gelatinase B)IBA 05/2007 - 11/2002
3	SirtuinsIBA 10/2019 - 12/2008
3	NADPH Oxidases (NAD(P)H oxidase)IBA 05/2012 - 01/2007
3	Huntingtin ProteinIBA 05/2012 - 01/2005
3	bardoxoloneIBA 07/2011 - 06/2009
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2009 - 08/2005
3	IronIBA 10/2009 - 03/2003
3	3-nitrotyrosineIBA 10/2009 - 05/2002
3	Peptides (Polypeptides)IBA 09/2009 - 08/2006
3	UbiquinoneIBA 06/2009 - 01/2003
3	Tissue Inhibitor of Metalloproteinase-1IBA 02/2008 - 11/2002
3	Tissue Inhibitor of Metalloproteinase-2IBA 02/2008 - 11/2002
3	CopperIBA 08/2007 - 09/2004
3	Adenosine Triphosphate (ATP)IBA 02/2007 - 11/2003
2	Mitochondrial Proteins (Mitochondrial Protein)IBA 10/2022 - 06/2006
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 08/2013
2	SynucleinsIBA 12/2020 - 04/2011
2	LipidsIBA 01/2020 - 12/2012
2	Dimethyl FumarateIBA 01/2018 - 01/2016
2	Thiamine (Aneurin)FDA Link 01/2018 - 10/2009
2	Phosphorus (Red Phosphorus)IBA 01/2015 - 05/2014
2	NF-E2-Related Factor 2IBA 07/2014 - 07/2011
2	Uric Acid (Urate)IBA 02/2014 - 12/2009
2	polyglutamineIBA 10/2013 - 09/2010
2	Pioglitazone (Actos)FDA Link 08/2013 - 02/2005
2	Transcription Factors (Transcription Factor)IBA 12/2012 - 08/2007
2	Carrier Proteins (Binding Protein)IBA 08/2012 - 05/2008
2	Mitochondrial Permeability Transition PoreIBA 05/2012 - 05/2002
2	Uncoupling Protein 2IBA 04/2012 - 11/2003
2	ProgranulinsIBA 12/2010 - 01/2010
2	Protein Glutamine gamma Glutamyltransferase 2IBA 09/2010 - 10/2005
2	ResveratrolIBA 09/2010 - 02/2009
2	Oxygen (Dioxygen)IBA 01/2010 - 07/2004
2	Succinate Dehydrogenase (Fumarate Reductase)IBA 01/2010 - 07/2002
2	Lenalidomide (CC 5013)FDA Link 11/2009 - 03/2006
2	MetalsIBA 10/2009 - 08/2007
2	Superoxide DismutaseIBA 08/2009 - 01/2007
2	alpha-SynucleinIBA 01/2009 - 03/2006
2	Lactic Acid (Lactate)FDA LinkGeneric 12/2008 - 02/2007

Therapy/Procedure

22	Therapeutics 01/2020 - 03/2003
6	Oral Administration 01/2018 - 03/2002